Melanotan-1 (Afamelanotide) is a synthetic peptide analog of alpha-melanocyte stimulating hormone with high selectivity for the MC1R receptor. Unlike Melanotan-2, MT-1 primarily targets the MC1R receptor responsible for melanogenesis, resulting in fewer off-target effects. Research has focused on its ability to stimulate eumelanin production and provide photoprotection. The peptide has been studied extensively in dermatological research, particularly for conditions involving photosensitivity. MT-1 represents a more targeted approach to melanocortin research compared to broader-acting analogs.